Bioactive Small Molecules
Medchemexpress LLC CXCR2 antagonist 2 | 2647464-91-1 | 99.3% | 364.39 g·mol⁻1 | C17H17FN2O4S | 5 MG
CXCR2 antagonist 2 is a selective small-molecule antagonist of the chemokine receptor CXCR2 for preclinical and in-vitro cancer immunoresearch. It inhibits CXCR2 with an IC50 of 95 nM and is supplied as a high-purity solid suitable for biochemical and cell-based assays.
- Potent CXCR2 inhibition (IC50 95 nM).
- High reported chemical purity (99.32%).
- Small-molecule solid, molecular weight 364.39 g·mol⁻1.
- Soluble in DMSO; available as a 10 mM solution.
- Available in small pack sizes for research use, including 5 mg.
- Intended for in vitro and preclinical assay applications.
Cayman Chemical ANTIBODY PlInabulIn 10mg
A tubulin depolymerizing agent; induces complete tubulin depolymerization in HUVECs (2 μM); induces HUVEC monolayer permeability in vitro; cytotoxic against a panel of cancer cell lines (IC50s = 4.3-18 nM); induces cell death in patient-derived multiple myeloma cells via inhibition of tubule formation and cell migration as well as induction of mitotic arrest and apoptosis in a JNK-dependent manner; reduces tumor size and increases survival in a MM.1S multiple myeloma mouse xenograft model (7.5 mg/kg)
Cayman Chemical ANTIBODY AF-DX 384 1mg
An M2 and M4 muscarinic acetylcholine receptor antagonist (Kis = 6.03 and 10 nM, respectively); selective for M2 and M4 over M1, M3, and M5 receptors (Kis = 30.9, 66.07, and 537.03 nM, respectively); increases acetylcholine release in the hippocampus and cortex of young and aged rats in vivo following local infusion at 1 µM and in the cortex at 5 mg/kg, i.p.; reverses deficits in novel object recognition and passive avoidance in aged rats, as well as scopolamine-induced deficits in young rats
Cayman Chemical ANTIBODY MK-0941 1mg
A glucokinase activator (EC50s = 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively); increases insulin secretion from isolated rat islets of Langerhans and glucose uptake by hepatocytes in vitro
![eMolecules 302795-84-2 | BDP FL alkyne | Broadpharm | MFCD28400774 | 329.160 | C17H18BF2N3O | 0.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCC#C)n1[B-]2(F)F | 1mg | 761705681](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502457952.PNG-250.jpg)
eMolecules 302795-84-2 | BDP FL alkyne | Broadpharm | MFCD28400774 | 329.160 | C17H18BF2N3O | 0.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCC#C)n1[B-]2(F)F | 1mg | 761705681
BDP FL alkyne | Broadpharm | 302795-84-2 | MFCD28400774 | 329.160 | C17H18BF2N3O | 0.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCC#C)n1[B-]2(F)F | 1mg | 761705681
![eMolecules 178039-84-4 | ChemScene | [22-Bipyridin]-6-amine | 100mg | 572242564 | CS-W018459 | MFCD01646269 | 171.203 | C10H9N3](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502456671.PNG-250.jpg)
eMolecules 178039-84-4 | ChemScene | [22-Bipyridin]-6-amine | 100mg | 572242564 | CS-W018459 | MFCD01646269 | 171.203 | C10H9N3
Medchem Express | ZK824190 (hydrochloride) | 5mg | 713704525 | HY-126361A | 2629177-12-2 | 450.870 | C22H21ClF2N2O4
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eMolecules Medchem Express | Protease-Activated Receptor-3 (PAR-3) (1-6) human (TFA) | 5mg | 596114135 | HY-P2519A | NaN | (C2HF3O2)XC29H46N10O7
Medchem Express | Protease-Activated Receptor-3 (PAR-3) (1-6) human (TFA) | 5mg | 596114135 | HY-P2519A | | NaN | (C2HF3O2)XC29H46N10O7
Apexbio Technology LLC TCS-PIM-1-4a 327033-36-3 10mM (in 1mL DMSO)
TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
Medchemexpress LLC Phospho-AKT1 (Ser473) antibody (YA228) | 100 UL
Phospho-AKT1 (Ser473) Antibody (YA228) is a rabbit-derived, non-conjugated IgG monoclonal antibody designed to target Phospho-AKT1 (Ser473). This antibody is suitable for western blot applications and reacts with human, mouse, and rat samples.
- Host: Rabbit
- Reactivity: Human, mouse, rat
- Application: Western blot
- Clonality: Monoclonal
- Isotype: IgG
- Conjugation: Non-conjugated
- Immunogen: Phospho-AKT1 (Ser473)
- Molecular weight: 56 kDa
- Formulation: Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA, with 0.01% Sodium azide preservative.
- Storage: Stored at -20°C for 1 year; avoid repeated freeze / thaw cycles.
- Shipping: Shipped with blue ice.
Cayman Chemical ANTIBODY TarIquIdar 10mg
A P-gp inhibitor; binds to P-glycoprotein (Kd = 5.1 nM); inhibits transport of vinblastine and paclitaxel in CHrB30 cells, leading to accumulation to control levels (EC50 = 487 nM); increases the amount of its substrate that enters the CNS
Medchemexpress LLC BMS-593214 1mg | 1004551-40-9 | 505.56 | C31H27N3O4 | 1 MG
This compound is an active site-directed Factor VIIa (FVIIa) inhibitor with antithrombotic and antihaemostatic activity for preclinical research use. It inhibits human FVIIa and modulates the VIIa-activated substrate FX; in vivo studies show prevention of carotid artery and vena cava thrombosis. Supplied as a solid and as DMSO solutions; consult the datasheet for storage and handling.
- High purity suitable for research applications.
- Direct competitive inhibitor of human FVIIa.
- Demonstrated antithrombotic activity in animal models.
- Soluble in DMSO at high concentration; ultrasonic treatment may be required.
- Available as solid quantities and as ready-to-use DMSO solutions.
- Store powder and solutions at recommended temperatures to preserve stability.
Apexbio Technology LLC FH1(BRD-K4477) 2719-05-3 10mM (in 1mL DMSO)
FH1 BRD-K4477 is a bioactive small molecule identified for its ability to enhance hepatocyte functionality FH1 BRD-K4477 promotes the expansion and functional maturation of cultured human hepatocytes maintaining liver-specific properties In studies involving induced pluripotent stem cell (iPSC)-derived hepatocytes (iHeps) FH1 BRD-K4477 supplementation increases albumin secretion and elevates the expression of drug-metabolizing enzyme CYP3A4 while reducing alpha-fetoprotein (AFP) secretion Based on these pharmacological properties FH1 BRD-K4477 is a valuable tool for research in liver biology hepatocyte maturation drug metabolism and regenerative medicine applications
Selleck Chemical LLC Sodium L-lactate
Sodium L-lactate is used as a food additive preservative acidity regulator and bulking agent
Selleck Chemical LLC STING inhibitor C-178 2mg
C-178 is a covalent inhibitor of STING,covalently bind to Cys91. *For Research & Development use only. Product is not intended for drug, household, or human consumption.